Cancer Immunology: A Translational Medicine Context by Nima Rezaei

By Nima Rezaei

Cancer Immunology is meant as an up to date, clinically appropriate evaluation of melanoma immunology and immunotherapy. This quantity is concentrated on immunopathology of cancers. The interactions among cancerous cells and numerous parts of the innate and adaptive immune approach are absolutely defined. The relevant concentration, even though, is especially a lot on medical facets, the purpose being to teach clinicians within the medical implications of the latest learn and new advancements within the box. during the last decade, realizing of the interactions among the immune method and cancerous cells has elevated markedly, resulting in the advance of combinatorial immunotherapeutic concepts to strive against melanoma. This translational, clinically orientated booklet could be of specific worth to scientific immunologists, hematologists and oncologists.

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Van Elsas A, Hurwitz AA, Allison JP. Combination immunotherapy of B16 melanoma using anticytotoxic T lymphocyte-associated antigen 4 (CTLA4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med. 1999;190(3):355–66. 30. Zou W, Chen L. Inhibitory B7-family molecules in the tumour microenvironment. Nat Rev Immunol. 2008;8(6):467–77. 31. Thompson RH, Kuntz SM, Leibovich BC, Dong H, Lohse CM, Webster WS, et al.

Cancer statistics, 2012. CA Cancer J Clin. 2012;62(1):10–29. 2. Ries LS, Smith MA, Gurney JG. Cancer Incidence and survival among children and adolescents: United States SEER Program 1975–1995. Bethesda: National Cancer Institute; 1999, Publ No 99-4649. 3. Howlader N, Noone AM, Krapcho M, et al. SEER cancer statistics review, 1975–2008. Bethesda: National Cancer Institute; 2011. 4. Ries L, Eisner MP, Kosary CL, et al. SEER cancer statistics review, 1975-2002, National Cancer Institute. gov/csr/1975_ 2002/, based on November 2004 SEER data submission, 2005.

Tumors may also produce immunosuppressive factors, such as interleukin10 (IL-10), transforming growth factor-β (TGF-β), and alpha-fetoprotein, which suppress innate immune responses against cancer. This has led to investigations using neutralizing antibodies against these immunosuppressive factors [7]. In contrast, tumor-specific cytotoxic T lymphocytes (CTLs) can be genetically altered to become resistant to the TGF-β inhibitory effect by transgene expression of a mutant dominant-negative TGF-ß type II receptor (DNR).

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