Breed Predispositions to Disease in Dogs and Cats by Alex Gough

By Alex Gough

Here's a entire connection with all of the illnesses and problems of canines and cats which are both inherited or extra accepted in convinced breeds. there's no different unmarried ebook that covers this topic. details on breed-related ailments from a number of fine quality resources are accrued jointly in a single position for the 1st time. while you are a veterinary physician or pupil wanting a convenient reference e-book, or a breeder eager to be aware of extra approximately your individual breed then this e-book may be helpful.

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Cases present, with haematuria and recurrent urinary tract infections more commonly than with uraemia, at 6 –15 months of age. Some cases present with cardiac disease. Hepatic cysts have not been seen in these cases Haematological conditions Pyruvate kinase deficiency • Inherited as an autosomal recessive trait Familial renal disease • Autosomal dominant inheritance • The condition is believed to be a glomerular basement-membrane disorder • Proteinuria may be an early indicator with cases progressing to renal failure at 1–8 years of age Musculoskeletal conditions Craniomandibular osteopathy • Aetiology unknown in this breed • Usually affects dogs aged 3–8 months CAIRN TERRIER Dermatological conditions Atopy • Common • May be more prevalent in females Endocrine conditions Diabetes mellitus • Possible breed predisposition • Usual age range: 4 –14 years; peak incidence: 7–9 years • Old, entire females are predisposed Gastrointestinal conditions Congenital bronchoesophageal fistula • Possible breed predisposition Congenital portosystemic shunt • Possible breed predisposition • Clinical signs usually seen in young dogs <1 year Microvascular portal dysplasia • Breed predisposition • Possibly inherited as a polygenic trait • May be asymptomatic Haemophilia B • Factor IX deficiency • Also known as Christmas disease • Inherited as a sex-linked trait • Less common than haemophilia A Inguinal hernia Neurological conditions Lysosomal storage disease – globoid cell leukodystrophy (Krabbe’s disease) • Autosomal recessive inheritance • Rare • Signs seen at 6–12 months Ocular conditions Refractory corneal ulceration • Breed predisposition • Usually middle-aged Ocular melanosis • Familial • Age of onset: 7–13 years • Predisposes to glaucoma • Schedule 3 of the BVA/KC/ISDS Eye Scheme Lens luxation • Autosomal dominant inheritance has been suggested • Age of onset: 4 –5 years Cataract • Inheritance suspected DOGS 43 Dogs 44 DOGS Retinal dysplasia • Mode of inheritance unknown, but autosomal recessive suspected Renal and urinary conditions Polycystic kidney disease • Autosomal recessive inheritance suggested • Cysts are found throughout the liver and kidneys from an early age (6 weeks).

0 MHz). 0 MHz). 3 • Most common in younger dogs • Lesions at the base of the pinna Oestrogen-responsive dermatosis • Usually occurs in the young adult Drug reactions Acepromazine and other phenothiazines (see figure 5) • This breed is very sensitive even to small doses of ACP Canine follicular dysplasia • Presumed genetic basis • Alopecia starts at 2–4 years of age and is restricted to the flank in this breed are most common in this breed Skin tumours • See under Neoplastic conditions Demodicosis • Possible breed predisposition Seasonal flank alopecia • May occur in autumn or spring Ehler-Danlos syndrome • Also known as cutaneous asthenia • A group of inherited diseases with various modes of inheritance Truncal solar dermatitis • Affects white boxers • Incidence of disease increases in sunny climates Callus dermatitis/pyoderma • Sternal calluses often become infected Idiopathic sterile granuloma and pyogranuloma • Uncommon • No age or sex predisposition Figure 5 Boxers are sensitive to even small doses of Acepromazine (ACP).

7 years in one study 19 Dogs 20 DOGS Coronary artery vasculitis • Asymptomatic • Unknown aetiology • Recognised in 34% of young Beagles Canine juvenile polyarteritis syndrome • Causes a pain syndrome • Reported in USA, France and UK Dermatological conditions Congenital hypotrichosis • Symmetrical hair loss • Usually hair loss is apparent at birth and gets worse over the following few weeks Black hair follicular dysplasia • Rare • Early onset • Familial Ehler-Danlos syndrome • Also known as cutaneous asthenia • Inherited • Various modes of inheritance Familial vasculopathy • Necrotising vasculitis of small- and mediumsized arteries • Early onset of signs Canine truncal solar dermatitis • Photosensitisation implicated • Worse in sunny climates Zinc-responsive dermatosis • In Beagles, occurs in puppies fed zincdeficient diets Skin tumours • See Neoplastic conditions Endocrine conditions Lymphocytic thyroiditis (causing hypothyroidism) • Demonstrated to be inherited polygenically in laboratory Beagles Thyroid neoplasia (may be associated with hyper- or hypothyroidism, but most are euthyroid) • Possible breed predisposition • Average age 10 years Hyperadrenocorticism: pituitary-dependent (PDH) • Possible breed predisposition • Middle-aged/older; median age 10 years • 55– 60% female Diabetes mellitus • Reported in some texts to be at increased risk • Usual age range: 4 –14 years; peak incidence: 7–9 years • Old entire females are predisposed Gastrointestinal conditions Chronic hepatitis • Increased incidence noted in this breed Haematological/immunological conditions Severe combined immunodeficiency • Inherited as an X-linked recessive trait • Thymic hypoplasia and lymphopaenia seen Selective IgA deficiency • Leads to chronic respiratory conditions and • dermatitis May be associated with autoimmunity Pyruvate kinase deficiency • Affected dogs have abnormal red blood cells with a lifespan of about 20 days Non-spherocytic haemolytic anaemia • Due to a defect in the ATPase calcium pump system in this breed Factor VII deficiency • Seen in families of laboratory dogs • Inherited as an autosomal dominant trait • Heterozygotes are asymptomatic Primary idiopathic hyperlipidaemia • Familial Infectious conditions Coccidiomycosis • Increased incidence in this breed possibly due to an increased likelihood of exposure • Mainly seen in young male dogs • Geographic distribution: California, Arizona, Texas, New Mexico, Nevada, Utah, Mexico and parts of Central and South America.

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