By L. Heilmeyer, H. Begemann, Helmut Löffler, Johann Rastetter, Torsten Haferlach
This sixth version of the atlas has built-in the 2001 WHO category and made use of figures and outlines to record lately defined sorts of leukemia and lymphoma. The latter comprise leukemias of dendritic cells, infrequent lymphomas and protracted polyclonal B lymphocytosis, which takes a different position within the classification.
The quantity covers the entire microscopic tools in hematology that shape the foundation of analysis in addition to the result of glossy immunologic, cytogenetic and molecular-genetic research. particular emphasis is put on the cytogenetic and molecular-genetic characterization of organic entities that will shape the root for leading edge therapies.
Normal effects and pathological findings are in comparison, and many of the findings made in the course of remedy are depicted. All in the entire Atlas of medical Hematology represents an entire and priceless reference paintings which might be found in each hematologic and oncologic division in addition to in scientific laboratories for on-line diagnostics and clinical research.
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Additional resources for Atlas of Clinical Hematology
9 b) is variable in its intensity. In very pronounced cases the neutrophils may come to resemble basophilic granulocytes. Cytoplasmic vacuoles in leukocytes, like toxic granulations, can develop in response to various toxic insults. They are often observed during long-term chloramphenicol therapy, phenylketonuria, diabetes mellitus, and in the setting of severe bacterial and viral infections. The vacuoles reflect a metabolic disturbance in the affected cells. Heparin artifact. Adding heparin to peripheral blood or especially bone marrow before preparing smears leads to artifacts when a panoptic stain is used (Giemsa or Pappenheim): the cells show scant or atypical staining, and a purple, crumbly precipitate forms on the background, making it difficult or impossible to identify the cells (Fig.
The inclusions also occur in monocytes and eosinophils, but they are very difficult to detect in these cells. They can be selectively demonstrated with methyl green-pyronine stain (red) (Fig. 12 a, b). Giant platelets are also detected (Fig. 12 c). ) in which bone marrow examination revealed a coarse, nonhomogeneous clumping of granules in the cytoplasm of the megakaryocytes (Fig. 12 d). 53 4 · Individual Cells Fig. 5 Cells of the Monocyte-Macrophage System (Fig. 13 a – h) Monocyte with phagocytized nuclear residue (Fig.
The nucleus appears coarse and smudgy, and there is partial clumping of the nuclear chromatin. As development progresses, the cell loses more of its basophilic cytoplasm and further diminishes in size (7 – 10 lm in diameter), gradually entering the stage of the orthochromatic normoblast (Fig. 4e). The nuclear- cytoplasmic ratio is further shifted in favor of the cytoplasm, which acquires an increasingly red tinge ultimately matching that of the mature erythrocyte. Supravital staining of the youngest erythrocytes reveals a network of strands (see p.