Analgesia by F Benedetti; Christoph Stein; et al

By F Benedetti; Christoph Stein; et al

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49 49 49 49 50 50 51 51 51 52 52 . . . . . . . . . . . . . . . . . . . . . 32 C. Zöllner · C. 2 Chronic Opioid Application .

2 Physical Dependence . . . . . . . . . . . . . . . . 53 53 54 References . . . . . . . . . . . . . . . . . . . . 54 Abstract Opioids are the most effective and widely used drugs in the treatment of severe pain. They act through G protein-coupled receptors. Four families of endogenous ligands (opioid peptides) are known. The standard exogenous opioid analgesic is morphine. Opioid agonists can activate central and peripheral opioid receptors. Three classes of opioid receptors (μ, δ, κ) have been identified.

J Neurophysiol 60:2180–2195 Schaible HG, Del Rosso A, Matucci-Cerinic M (2005) Neurogenic aspects of inflammation. Rheum Dis Clin North Am 31:77–101 Segond von Banchet G, Petrow PK, Bräuer R, Schaible HG (2000) Monoarticular antigeninduced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats. Arthritis Res 2:424–427 Sivilotti LG, Thompson SWN, Woolf CJ (1993) The rate of rise of the cumulative depolarization evoked by repetitive stimulation of small-calibre afferents is a predictor of action potential windup in rat spinal neurons in vitro.

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