Aldol Reactions by Rainer Mahrwald

By Rainer Mahrwald

Aldol Reactions presents a finished updated review of aldol reactions together with software of other steel enolates; catalytic aldol additions catalyzed by means of diverse Lewis acids and Lewis bases; enantioselective direct aldol additions; antibodies and enzyme catalyzed aldol additions and the hot competitive improvement of organocatalyzed aldol additions. the facility of every process is validated through numerous functions in overall synthesis of common items. the professionals and cons of those methodologies in regards to stereoselectivity, regioselectivity and alertness in overall synthesis of normal items are mentioned. nice significance is decided to the varied probabilities of the guide of aldol response to put in required configurations in advanced traditional product synthesis.

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Paterson I, Florence GJ (2003) Eur J Org Chem 2193 55. (a) Paterson I, Wren SP (1993) Chem Commun 1790; (b) Paterson I, Schlapbach A (1995) Synlett 498 56. (a) Paterson I, Chen DYK, Coster MJ, Acena JL, Bach J, Gibson KR, Keown LE, Oballa RM, Trieselmann A, Wallace DJ, Hodgson AP, Norcross RD (2001) Angew Chem Int Ed Engl 40:4055; (b) Paterson I, Coster MJ, Chen DYK, Gibson KR, Wallace DJ (2005) Org Biomol Chem 3:2410; (c) Paterson I, Coster MJ, Chen DYK, Oballa RM, Wallace DJ, Norcross RD (2005) Org Biomol Chem 3:2399 57.

A) Florence GJ, Gardner NM, Paterson I (2008) Nat Prod Rep 25:342; (b) Yeung KS, Paterson I (2005) Chem Rev 105:4237; (c) Norcross RD, Paterson I (1995) Chem Rev 95:2041 53. (a) Paterson I, Wallace DC, Cowden CD (1998) Synthesis 639; (b) Paterson I, Norcross RD, Ward RA, Romea P, Lister MA (1994) J Am Chem Soc 116:11287 54. Paterson I, Florence GJ (2003) Eur J Org Chem 2193 55. (a) Paterson I, Wren SP (1993) Chem Commun 1790; (b) Paterson I, Schlapbach A (1995) Synlett 498 56. (a) Paterson I, Chen DYK, Coster MJ, Acena JL, Bach J, Gibson KR, Keown LE, Oballa RM, Trieselmann A, Wallace DJ, Hodgson AP, Norcross RD (2001) Angew Chem Int Ed Engl 40:4055; (b) Paterson I, Coster MJ, Chen DYK, Gibson KR, Wallace DJ (2005) Org Biomol Chem 3:2410; (c) Paterson I, Coster MJ, Chen DYK, Oballa RM, Wallace DJ, Norcross RD (2005) Org Biomol Chem 3:2399 57.

Transition state models C and F can be differentiated by the orientation of the chiral centre towards the metal centre favouring the transition state C (allylic strain). 7). 6). O O O O O O O B i- Pr O O 14 + N H 2. i-Pr-CHO Et2AICI 15 i-Pr Me N i- Pr i -Pr N Bu Bu 1. 8). 44 28 2 Aldol Reactions with Preformed Enolates 1. Et2BOTf, i-Pr2NEt 2. R1-CHO R1 N SO2 O 17 OH 1. Et2BOTf, i-Pr2NEt N SO2 O 2. 3 Boron Enolates 29 Tremendous comprehensive investigations on the stereochemical outcome of boron enolate aldol additions were carried out by Evans and coworkers.

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