Airway Mucus: Basic Mechanisms and Clinical Perspectives by John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr.

By John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. Michael I. Lethem (eds.)

Conceptually unsavoury, airway mucus is key to homeostasis within the respiration tract. by contrast, whilst irregular, mucus contributes considerably to the pathophysiology of a few critical bronchial ailments, together with bronchial asthma, power bronchitis and cystic fibrosis. This quantity presents vast ranging and in-depth assurance of the clinical and medical points of airway mucus. It commences with introductory chapters which handle the biochemical and molecular organic foundation of airway mucus and maintains with accomplished assurance of a number of the physiological and rheological facets of respiration secretions. The scientific points of the subject are then thought of, with chapters discussing the involvement of mucus secretions in bacterial an infection and in hypersecretory illnesses of the airway. the amount concludes with a dialogue of the healing points of the subject, either when it comes to the potential methods to the remedy of mucus hypersecretion and the interplay of those medicinal drugs with airway mucus. Written by way of major specialists within the box, each one contribution presents a entire assessment of its specific topic. Reflecting the most recent advances during this very important zone of breathing learn, this quantity should be of serious curiosity to scientists and clinicians operating within the box of airway secretions and similar areas.

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Extra info for Airway Mucus: Basic Mechanisms and Clinical Perspectives

Sample text

It is clear, considering the number of different apomucins expressed in the respiratory tract, that these studies were probably performed on mixtures of mucins rather than on distinct populations. Thus, 24 D. J. Thornton et al. DQ Core region r- , ~~... ~"-. ~ /GaINAC Ct-O-ser/thr -

53. Scharfmann A, Lamblin G, Roussel P (1995) Interactions between human respiratory mucins and pathogens. Biochem Soc Trans 23: 836-839. 54. Lo-Guidice J-M, Wieruszeski J-M, Lemoine J, Verbert A, Roussel P, Lamblin G (1994) Sialylation and sulfation of the carbohydrate chains in respiratory mucins from a patient with cystic fibrosis. J Bioi Chem 269: 18794-18813. 55. Dekker J, Strous GJ (1990) Covalent oligomerization of rat gastric mucin occurs in the rough ER, is N-glycosylation dependent, and precedes initial O-glycosylation.

59. Mazzuca M, Lhermitte M, Lafitte J-J, Roussel P (1982) Use of lectins for detection of glycoconjugates in the glandular cells of human bronchial mucosa. J Histochem Cytochem 30: 956-966. 60. Thornton DJ, Sheehan JK, Carlstedt I (1991) Heterogeneity of mucus glycoproteins from cystic fibrotic sputum. Biochem J276: 677-682. 61. Sheehan JK, Thornton DJ, Carlstedt I (1990) Histochemical methods used in biochemical approaches to mucus glycoproteins. Acta Histochemica Suppl-Band XL, S. 133-135. 62.

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