AIDS Vaccine Research by Flossie Wong-Staal, Robert C. Gallo

By Flossie Wong-Staal, Robert C. Gallo

This reference describes the newest advances within the improvement and layout of an HIV preventive vaccine-detailing the pathogenesis and genetic variability of HIV an infection for the development of molecular and healing suggestions to lessen the development and transmission of AIDS. With contributions by way of universally well-known professionals within the box, AIDS Vaccine learn discusses

  • major hindrances within the id of a preventive vaccine
  • the function of innate immunity in administration of HIV an infection
  • the effect of hugely energetic antiretroviral remedy (HAART) on AIDS examine
  • the production of an efficient mucosal DNA vaccine
  • the impression of the AIDS epidemic on constructing nations supplying approximately 2000 modern references to facilitate additional examine, AIDS Vaccine examine is a well timed handbook compatible for immunologists, virologists, pathologists, epidemiologists, pharmacologists, microbiologists, hematologists, hepatologists, AIDS researchers, and upper-level undergraduate and graduate scholars in those disciplines.
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    Sample text

    DC are thus able to efficiently transport HIV to lymphoid organs, facilitating infection of CD4ϩ T cells and viral dissemination. DC also express several different chemokine receptors that can be used as HIV coreceptors for entry (61,527,528). Although the frequency of HIV-infected DC in vivo may be low, these cells nevertheless may represent an important viral reservoir. , DC resident in the epidermis) may be dependent on viral subtype (529). This finding could in part explain the differences in the global epidemiology of HIV infection; an HIV subtype that can replicate well in Langerhans cells, likely a major cell type involved in the initiation of viral infection through mucosal contact (108), may be more efficiently transmitted heterosexually.

    A wide array of immune system deficits are associated with HIV infection; abnormalities in the function of all limbs of the immune system, including T and B lymphocytes, antigen-presenting cells, natural killer cells, and neutrophils, have been described. CD4؉ T Cells CD4ϩ T cell dysfunction and depletion are hallmarks of HIV disease. The proximate cause of the susceptibility to opportunistic infections observed with advancing disease is the defects in T-cell number and function that result directly or indirectly from HIV infection.

    Lane. 1998. Human immunodeficiency virus (HIV) disease: AIDS and related disorders. In: Harrison’s Principles and Practice of Internal Medicine. 14th ed. ) Immunopathogenesis of HIV Infection 23 is able to continuously replicate and cause the inexorable decline in immune system function in the presence of these immune responses. Humoral Immune Responses Antibodies against the viral core protein p24 develop within weeks of acute HIV infection and may play a role in the decline of plasma viremia associated with primary infection (127,179–181).

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