Acute Myelogenous Leukemia (Contemporary Hematology) by Judith E. Karp

By Judith E. Karp

This is a well timed compilation of recent techniques within the molecular pathogenesis and molecular remedy of acute myelogenous leukemia (AML). the point of interest is on chosen serious molecular determinants of AML pathogenesis and pathophysiology and the exploitation of those elements by way of diversified healing brokers and modalities. there's an emphasis all through at the bidirectional move of information among the medical and laboratory arenas.

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Mechanisms of action of, and modes of resistance to, alkylating agents used in the treatment of hematological malignancies. Blood Rev 1992;6:63-73. 59. Shyam K, Cosby LA, Sartorelli AC. Synthesis and evaluation of N,N' -bis(arylsulfonyl)hydrazines as antineoplastic agents. J Med Chern 1985;28:525-527. 60. Shyam K, Furubayashi R, Hrubiec RT, Cosby LA, Sartorelli AC. 1,2-Bis(arylsulfonyl)hydrazines. 2. The influence of arylsulfonyl and aralkylsulfonyl substituents on antitumor and alkylating activity.

Molecular biology of the cell. In: Alberts B, Bray D, Lewis I, Raff M, Roberts K, Watson JD, eds. , 1994:721-785. Ravandi F, Talpaz M, Estrov Z. Modulation of cellular signaling pathways: prospects for targeted therapy in hematological malignancies. Clin Cancer Res 2003;9:535-550. Scheijen B, Griffin ID. Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease. Oncogene 2002;21 :3314-3333. Frank DA. STAT signaling in the pathogenesis and treatment of cancer. Mol Med 1999;5:432-456.

Chapter 1 I AML Treatment: Biological Perspective 17 41. Issa IP, Garcia-Manero G, Mannari R, et al. Minimal effective dose of the hypomethylating agent decitabine in hematopoietic malignancies. Blood 2001;98:594-595. 42. Issa IP, Garcia-Manero G, Giles Fl, et al. Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2' -deoxycytidine (decitabine) in hematopoietic malignancies. Blood 2004; I03(5): 1635-1640. 43. Silverman LR, Demakos EP, Peterson BL, et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B.

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