Active Surveillance for Localized Prostate Cancer: A New by Laurence Klotz M.D., F.R.C.S.C. (auth.), Laurence Klotz

By Laurence Klotz M.D., F.R.C.S.C. (auth.), Laurence Klotz (eds.)

Active Surveillance for Localized Prostate melanoma: a brand new Paradigm for scientific administration will function an invaluable source for physicians facing, and drawn to, this advanced and evolving department of prostate melanoma administration. The publication can also be of curiosity to scientifically literate sufferers and their households. the amount presents an advent to the concept that of lively surveillance in oncology quite often and prostate melanoma in particular. the first concentration is to supply a finished advisor to the administration of sufferers on surveillance. the quantity covers the numerous complexities and nuances to this strategy together with, sufferer choice, possibility evaluate, how you can triumph over 'cancer hysteria' while counseling sufferers, picking acceptable triggers for intervention, use of PSA kinetics and MR imaging details, method and frequency of biopsies, secondary prevention interventions, and the relative roles of surveillance and focal therapy.

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Lu-Yao GL, Albertsen PC, Moore DF, et al. Outcomes of localized prostate cancer following conservative management. JAMA. 2009 Sep 16;302(11):1202–9. 26. Stattin P, Holmberg E, Johansson JE, Holmberg L, Adolfsson J, Hugosson J. Outcomes in localized prostate cancer: National Prostate Cancer Register of Sweden follow-up study. J Natl Cancer Inst. 2010 Jul 7;102(13):950–8. 19 27. Bill-Axelson A, Holmberg L, Filen F, et al. Radical prostatectomy versus watchful waiting in localized prostate cancer: the Scandinavian prostate cancer group-4 randomized trial.

12 (Fig. 3a). By focusing our efforts on a cohort with a high percentage of intermediate-risk patient’s all treated with surgery as curative, we optimized our ability to accurately discriminate patients with indolent vs. aggressive disease. 47 (Fig. 3b). , AR and Ki67) in the discrimination of disease progression risk among intermediate-grade prostate cancers. The investigation of AR in diagnostic prostate tissue both as an indicator for innate tumor aggressiveness and association with response to hormonal therapy has been studied for over 25 years.

Perspectives on utilizing unique features of microfluidics technology for particle and cell sorting. JALA. 2009;14:331–40. 52. Wang S, Owens GE, Tseng HR. Nano “fly paper” technology for the capture of circulating tumor cells. Methods Mol Biol. 2011;726:141–50. 53. Stott SL, Lee RJ, Nagrath S, Yu M, Miyamoto DT, Ulkus L, Inserra EJ, Ulman M, Springer S, Nakamura Z, Moore AL, Tsukrov DI, Kempner ME, et al. Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer.

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