ABC of Transfusion (ABC Series) by Marcela Contreras

By Marcela Contreras

Blood prone and Transfusion drugs became extra medical, medical, good organised and consolidated during the last twenty years. extra is understood concerning the frequency and aetiology of the risks of blood transfusions. The ABC of Transfusion is a good validated creation for all employees operating in blood companies, blood transfusion departments, surgical devices and extensive care, and all prescribers and clients of blood. it's a entire, extremely popular advisor to all of the functional facets of blood transfusion, together with many of the issues that could arise.This fourth variation of ABC of Transfusion comprises 5 new chapters on all of the most up-to-date matters together with pre-transfusion checking out, vCJD, stem phone transplantation, immunotherapy, and acceptable use of blood - reflecting the truth that transfusion medication has been revolutionised. invaluable as a realistic consultant, a refresher or for fast reference, it covers all crucial transfusion issues and is a perfect resource of data for all future health pros concerned with secure and effective use of blood.

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Cytomegalovirus (CMV) persists in the leucocytes of some of the individuals who have had an infection in the past. Transmission of CMV by transfusion to immunocompromised recipients may cause a severe and sometimes fatal infection. Therefore, transfusion of platelets collected from CMV-negative donors or knowingly leucodepleted platelet concentrates are indicated for these patients. Bacterial contamination and endotoxic transmission are major risks of platelet transfusions because platelets are stored at room temperature, facilitating bacterial growth.

2); the paediatric dose is 10–15 ml/kg. ABO and RhD identical units should be used as far as is possible. To prevent acute haemolysis group O platelets should not be used, or used only as a last resort, for groups A, B or AB patients. In emergencies, group O platelets may be used for non-O recipients if the units have been tested and labelled as negative for high titre anti-A and anti-B. RhD-negative subjects given RhD-positive platelets may very rarely develop anti-D through sensitization by red cells present in the platelet concentrate.

The most common adverse effect of platelet transfusion is the development of immunological reactions such as non-haemolytic febrile transfusion reactions (NHFTRs). Febrile reactions can be caused by white cell antibodies, mainly HLAs, present in the recipient 25 and reacting with donor leucocytes, or, rarely, by interleukins and tumour necrosis factor released by leucocytes present in the platelet concentrate during storage. Other adverse effects are platelet refractoriness, TA-GvHD and allergic or anaphylactic reactions to plasma proteins such as immunoglobulin A (see Chapter 11).

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