Focal Points 2010 : Clinical Modules for Ophthalmologists by American Academy of Ophthalmology

By American Academy of Ophthalmology

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J Bioi Chern. 1991; 266: 12866-72. 3. Hla T, Neilson K. Human cyclooxygenase-2 cDNA. Proc Nat! Acad Sci USA. 1992; 89: 7384-8. 4. Goppelt-Struebe M. Regulation of Prostaglandin Endoperoxide Synthase (Cyclooxygenase) Isozyme expression. Prostaglandins, Leukotrienes and Essential Fatty Acids. 1995; 52: 213-22. 5. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New BioI. 1971; 231: 232-5. 6. Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR.

21. Huff R, Collins P, Kramer S et al. A structural feature of N-[2-Scyclohexyloxy)-4nitrophenyl] methanesulfonamide (NS-39S) that governs its selectivity and affinity for cyclooxygenase 2(COX2). Inflamm Res. 2): SI45-6. 22. Prasit P, Black WC, Chan CC et al. L-745,337: A selective cyclooxygenase-2 inhibitor. Med Chern Res. 1995; 5: 364-74. 23. Christoph T, Bodenteich A, Berg 1. A whole cell assay system to test for specific COX inhibitors using the human monocytic cell line Mono Mac 6 and the human megacaryocytic cell line DAM!.

Kargman S, Wong E, Greig GM et al. Mechanism of selective inhibition of human prostaglandin G/H synthase-l and -2 in intact cells. Biochem Pharmacol. 1996; 52: 1113-25. DIFFERENTIAL INHIBITION OF COX-1 AND COX-2 BY NSAIDs 45 33. Tavares lA, Bennett A. Acemetacin and indomethacin: Differential inhibition of constitutive and inducible cyclo-oxygenases in human gastric mucosa and leucocytes. Int J Tiss Reac. 1993; 15: 49-53. 34. Tavares lA, Bishai PM, Bennett A. Activity of nimesulide on constitutive and inducible cyclooxygenases.

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